mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK

Mammalian target of rapamycin complex 1 (mTORC1) inhibitors are extensively used as immunosuppressants to prevent transplant rejection and in treatment of certain cancers. In patients, chronic treatment with rapamycin or its analogues (rapalogues) has been reported to lead to sensory hypersensitivit...

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Autori principali: Melemedjian, Ohannes K., Khoutorsky, Arkady, Sorge, Robert E., Yan, Jin, Asiedu, Marina N., Valdez, Arely, Ghosh, Sourav, Dussor, Gregory, Mogil, Jeffrey S., Sonenberg, Nahum, Price, Theodore J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3742001/
https://ncbi.nlm.nih.gov/pubmed/23607966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2013.03.021
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