Resistance Mutation R292K Is Induced in Influenza A(H6N2) Virus by Exposure of Infected Mallards to Low Levels of Oseltamivir

Resistance to neuraminidase inhibitors (NAIs) is problematic as these drugs constitute the major treatment option for severe influenza. Extensive use of the NAI oseltamivir (Tamiflu®) results in up to 865 ng/L of its active metabolite oseltamivir carboxylate (OC) in river water. There one of the nat...

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Main Authors: Gillman, Anna, Muradrasoli, Shaman, Söderström, Hanna, Nordh, Johan, Bröjer, Caroline, Lindberg, Richard H., Latorre-Margalef, Neus, Waldenström, Jonas, Olsen, Björn, Järhult, Josef D.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741332/
https://ncbi.nlm.nih.gov/pubmed/23951116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071230
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