Resistance Mutation R292K Is Induced in Influenza A(H6N2) Virus by Exposure of Infected Mallards to Low Levels of Oseltamivir

Resistance to neuraminidase inhibitors (NAIs) is problematic as these drugs constitute the major treatment option for severe influenza. Extensive use of the NAI oseltamivir (Tamiflu®) results in up to 865 ng/L of its active metabolite oseltamivir carboxylate (OC) in river water. There one of the nat...

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Главные авторы: Gillman, Anna, Muradrasoli, Shaman, Söderström, Hanna, Nordh, Johan, Bröjer, Caroline, Lindberg, Richard H., Latorre-Margalef, Neus, Waldenström, Jonas, Olsen, Björn, Järhult, Josef D.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2013
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741332/
https://ncbi.nlm.nih.gov/pubmed/23951116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071230
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