Inhibition of Both EGFR and IGF1R Sensitized Prostate Cancer Cells to Radiation by Synergistic Suppression of DNA Homologous Recombination Repair

Reduced sensitivity of prostate cancer (PC) cells to radiation therapy poses a significant challenge in the clinic. Activation of epidermal growth factor receptor (EGFR), type 1 insulin-like growth factor receptor (IGF1R), and crosstalk between these two signaling pathways have been implicated in th...

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Detalhes bibliográficos
Main Authors: Wang, Yong, Yuan, Jian Lin, Zhang, Yun Tao, Ma, Jian Jun, Xu, Peng, Shi, Chang Hong, Zhang, Wei, Li, Yu Mei, Fu, Qiang, Zhu, Guang Feng, Xue, Wei, Lei, Yong Hua, Gao, Jing Yu, Wang, Juan Ying, Shao, Chen, Yi, Cheng Gang, Wang, He
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741308/
https://ncbi.nlm.nih.gov/pubmed/23950876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0068784
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