Metformin Protects Rat Hepatocytes against Bile Acid-Induced Apoptosis

BACKGROUND: Metformin is used in the treatment of Diabetes Mellitus type II and improves liver function in patients with non-alcoholic fatty liver disease (NAFLD). Metformin activates AMP-activated protein kinase (AMPK), the cellular energy sensor that is sensitive to changes in the AMP/ATP-ratio. A...

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Bibliographic Details
Main Authors: Woudenberg-Vrenken, Titia E., Conde de la Rosa, Laura, Buist-Homan, Manon, Faber, Klaas Nico, Moshage, Han
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741108/
https://ncbi.nlm.nih.gov/pubmed/23951244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071773
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