CRITICAL ROLE OF STAT3 IN IL-6-MEDIATED DRUG RESISTANCE IN HUMAN NEUROBLASTOMA

Drug resistance is a major cause of treatment failure in cancer. Here we have evaluated the role of STAT3 in environment-mediated drug resistance (EMDR) in human neuroblastoma. We determined that STAT3 was not constitutively active in most neuroblastoma cell lines but was rapidly activated upon trea...

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Autors principals: Ara, Tasnim, Nakata, Rie, Sheard, Michael A., Shimada, Hiroyuki, Buettner, Ralf, Groshen, Susan G., Ji, Lingyun, Yu, Hua, Jove, Richard, Seeger, Robert C., DeClerck, Yves A.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740971/
https://ncbi.nlm.nih.gov/pubmed/23633489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-2353
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