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Cost of rNTP/dNTP pool imbalance at the replication fork

The concentration of ribonucleoside triphosphates (rNTPs) in cells is far greater than the concentration of deoxyribonucleoside triphosphates (dNTPs), and this pool imbalance presents a challenge for DNA polymerases (Pols) to select their proper substrate. This report examines the effect of nucleoti...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yao, Nina Y., Schroeder, Jeremy W., Yurieva, Olga, Simmons, Lyle A., O’Donnell, Mike E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740908/
https://ncbi.nlm.nih.gov/pubmed/23882084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1309506110
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