Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2–mediated suppression of mTORC1

Reactive intermediates such as reactive nitrogen species play essential roles in the cell as signaling molecules but, in excess, constitute a major source of cellular damage. We found that nitrosative stress induced by steady-state nitric oxide (NO) caused rapid activation of an ATM damage-response...

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Autors principals: Tripathi, Durga N., Chowdhury, Rajdeep, Trudel, Laura J., Tee, Andrew R., Slack, Rebecca S., Walker, Cheryl Lyn, Wogan, Gerald N.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740898/
https://ncbi.nlm.nih.gov/pubmed/23878245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1307736110
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