Shear stress activation of nuclear receptor PXR in endothelial detoxification

Endothelial cells (ECs) are constantly exposed to xenobiotics and endobiotics or their metabolites, which perturb EC function, as well as to shear stress, which plays a crucial role in vascular homeostasis. Pregnane X receptor (PXR) is a nuclear receptor and a key regulator of the detoxification of...

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Bibliographische Detailangaben
Hauptverfasser: Wang, Xiaohong, Fang, Xi, Zhou, Jing, Chen, Zhen, Zhao, Beilei, Xiao, Lei, Liu, Ao, Li, Yi-Shuan J., Shyy, John Y.-J., Guan, Youfei, Chien, Shu, Wang, Nanping
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740860/
https://ncbi.nlm.nih.gov/pubmed/23878263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312065110
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