Shear stress activation of nuclear receptor PXR in endothelial detoxification

Endothelial cells (ECs) are constantly exposed to xenobiotics and endobiotics or their metabolites, which perturb EC function, as well as to shear stress, which plays a crucial role in vascular homeostasis. Pregnane X receptor (PXR) is a nuclear receptor and a key regulator of the detoxification of...

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Bibliographic Details
Main Authors: Wang, Xiaohong, Fang, Xi, Zhou, Jing, Chen, Zhen, Zhao, Beilei, Xiao, Lei, Liu, Ao, Li, Yi-Shuan J., Shyy, John Y.-J., Guan, Youfei, Chien, Shu, Wang, Nanping
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740860/
https://ncbi.nlm.nih.gov/pubmed/23878263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312065110
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