Shear Stress Induces Synthetic-to-Contractile Phenotypic Modulation in Smooth Muscle Cells via PPAR-α/δ Activations by Prostacyclin Released by Sheared Endothelial Cells

RATIONALE: Phenotypic modulation of smooth muscle cells (SMCs), which are located in close proximity to endothelial cells (ECs), is critical in regulating vascular function. The role of flow-induced shear stress in the modulation of SMC phenotype has not been well defined. OBJECTIVE: The objective w...

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Autori principali: Tsai, Min-Chien, Chen, Lihong, Zhou, Jing, Tang, Zhihui, Hsu, Tzu-Fang, Wang, Ying, Shih, Yu-Tsung, Peng, Hsin-Hsin, Wang, Nanping, Guan, Youfei, Chien, Shu, Chiu, Jeng-Jiann
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772782/
https://ncbi.nlm.nih.gov/pubmed/19628794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.193656
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