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Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery
In fragment-based drug discovery, the weak affinities exhibited by fragments pose significant challenges for screening. Biophysical techniques are used to address this challenge, but there is no clear consensus on which cascade of methods is best suited to identify fragment hits that ultimately tran...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3740835/ https://ncbi.nlm.nih.gov/pubmed/23872845 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1304045110 |
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