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Synthetic lethality of rpn11-1 rpn10Δ is linked to altered proteasome assembly and activity
An rpn11-1 temperature-sensitive mutant shows defect in proteolysis, mitochondrial function and proteasome assembly. The Rpn11 protein is a proteasome subunit that deubiquitinates proteolytic substrates. Multiubiquitinated proteins interact with proteasome receptors, such as Rpn10, which intriguingl...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3740776/ https://ncbi.nlm.nih.gov/pubmed/20941496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00294-010-0321-3 |
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