Development and Validation of a Highly Sensitive Liquid Chromatography/Mass Spectrometry Method for Simultaneous Quantification of Lenalidomide and Flavopiridol in Human Plasma

Lenalidomide, an immunomodulatory agent, and flavopiridol, a broad cyclin-dependent kinase inhibitor, are both active therapies for clinical use in genomic high risk chronic lymphocytic leukemia (CLL). A high-performance liquid chromatographic assay with tandem mass spectrometric detection has been...

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Main Authors: Liu, Qing, Farley, Katherine L., Johnson, Amy J., Muthusamy, Natarajan, Hofmeister, Craig C., Blum, Kristie A., Schaaf, Larry J., Grever, Michael R., Byrd, John C., Dalton, James T., Phelps, Mitch A.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740534/
https://ncbi.nlm.nih.gov/pubmed/18708993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FTD.0b013e318185813d
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