Development and validation of a rapid and sensitive high-performance liquid chromatography-mass spectroscopy assay for determination of 17-(allylamino)-17-demethoxygeldanamycin and 17-(amino)-17-demethoxygeldanamycin in human plasma

A sensitive method was developed and validated for the measurement of 17-(allylamino)-17-demethoxygeldanamycin (17AAG) and its active metabolite 17-amino-17-demethoxygeldanamycin (17AG) in human plasma using 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17DMAG) as an internal standard. Afte...

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Bibliographic Details
Main Authors: Johnston, Jeffrey S., Phelps, Mitch A., Blum, Kristie A, Blum, William, Grever, Michael R., Farley, Katherine L., Dalton, James T
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3782378/
https://ncbi.nlm.nih.gov/pubmed/18635408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2008.06.029
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