Development and validation of a sensitive liquid chromatography/mass spectrometry method for quantitation of flavopiridol in plasma enables accurate estimation of pharmacokinetic parameters with a clinically active dosing schedule

A high-performance liquid chromatographic assay with tandem mass spectrometric detection was developed and validated for quantitation of the broad spectrum kinase inhibitor, flavopiridol, in human plasma. Sample preparation conditions included liquid-liquid extraction in acetonitrile (ACN), drying,...

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Main Authors: Phelps, Mitch A, Rozewski, Darlene M., Johnston, Jeffrey S., Farley, Katherine L., Albanese, Katie A., Byrd, John C., Lin, Thomas S., Grever, Michael R., Dalton, James T.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504738/
https://ncbi.nlm.nih.gov/pubmed/18490204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2008.04.023
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