Phase I clinical and pharmacokinetic study of a novel schedule of flavopiridol in relapsed or refractory acute leukemias

BACKGROUND: A pharmacokinetically derived schedule of flavopiridol administered as a 30 min intravenous bolus followed by 4-hour continuous intravenous infusion (IVB/CIVI) is active in fludarabine-refractory chronic lymphocytic leukemia, but no studies examining the feasibility and maximum tolerated...

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Detalhes bibliográficos
Main Authors: Blum, William, Phelps, Mitch A., Klisovic, Rebecca B., Rozewski, Darlene M., Ni, Wenjun, Albanese, Katie A., Rovin, Brad, Kefauver, Cheryl, Devine, Steven M., Lucas, David M., Johnson, Amy, Schaaf, Larry J., Byrd, John C., Marcucci, Guido, Grever, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2010
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895033/
https://ncbi.nlm.nih.gov/pubmed/20460644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2009.017103
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