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Phase I clinical and pharmacokinetic study of a novel schedule of flavopiridol in relapsed or refractory acute leukemias

BACKGROUND: A pharmacokinetically derived schedule of flavopiridol administered as a 30 min intravenous bolus followed by 4-hour continuous intravenous infusion (IVB/CIVI) is active in fludarabine-refractory chronic lymphocytic leukemia, but no studies examining the feasibility and maximum tolerated...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Blum, William, Phelps, Mitch A., Klisovic, Rebecca B., Rozewski, Darlene M., Ni, Wenjun, Albanese, Katie A., Rovin, Brad, Kefauver, Cheryl, Devine, Steven M., Lucas, David M., Johnson, Amy, Schaaf, Larry J., Byrd, John C., Marcucci, Guido, Grever, Michael R.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Ferrata Storti Foundation 2010
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895033/
https://ncbi.nlm.nih.gov/pubmed/20460644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2009.017103
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