Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling

Acid ceramidase (AC) is overexpressed in most prostate tumors and confers oncogenic phenotypes to prostate cancer cells. AC modulates the cellular balance between ceramide, sphingosine and sphingosine 1-phosphate (S1P). These bioactive sphingolipids have diverse, powerful and often oppositional impa...

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Hlavní autoři: Beckham, T H, Cheng, J C, Lu, P, Shao, Y, Troyer, D, Lance, R, Marrison, S T, Norris, J S, Liu, X
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740300/
https://ncbi.nlm.nih.gov/pubmed/23732709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2013.14
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