Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling

Acid ceramidase (AC) is overexpressed in most prostate tumors and confers oncogenic phenotypes to prostate cancer cells. AC modulates the cellular balance between ceramide, sphingosine and sphingosine 1-phosphate (S1P). These bioactive sphingolipids have diverse, powerful and often oppositional impa...

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Detalhes bibliográficos
Main Authors: Beckham, T H, Cheng, J C, Lu, P, Shao, Y, Troyer, D, Lance, R, Marrison, S T, Norris, J S, Liu, X
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740300/
https://ncbi.nlm.nih.gov/pubmed/23732709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2013.14
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