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Backpropagating Action Potentials Enable Detection of Extrasynaptic Glutamate by NMDA Receptors

Synaptic NMDA receptors (NMDARs) are crucial for neural coding and plasticity. However, little is known about the adaptive function of extrasynaptic NMDARs occurring mainly on dendritic shafts. Here, we find that in CA1 pyramidal neurons, backpropagating action potentials (bAPs) recruit shaft NMDARs...

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Autors principals: Wu, Yu-Wei, Grebenyuk, Sergei, McHugh, Thomas J., Rusakov, Dmitri A., Semyanov, Alexey
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740263/
https://ncbi.nlm.nih.gov/pubmed/22832274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.03.007
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