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Backpropagating Action Potentials Enable Detection of Extrasynaptic Glutamate by NMDA Receptors

Synaptic NMDA receptors (NMDARs) are crucial for neural coding and plasticity. However, little is known about the adaptive function of extrasynaptic NMDARs occurring mainly on dendritic shafts. Here, we find that in CA1 pyramidal neurons, backpropagating action potentials (bAPs) recruit shaft NMDARs...

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Bibliografiske detaljer
Main Authors: Wu, Yu-Wei, Grebenyuk, Sergei, McHugh, Thomas J., Rusakov, Dmitri A., Semyanov, Alexey
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740263/
https://ncbi.nlm.nih.gov/pubmed/22832274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.03.007
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