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Toll-like Receptor-4 Mediates Neutrophil Sequestration and Lung Injury Induced by Endotoxin and Hyperinflation

OBJECTIVE: Infiltration of polymorphonuclear neutrophils into the lung is an important feature of ventilator-induced lung injury associated with pneumonia, but the mechanisms involved in neutrophil recruitment are poorly understood. Using Toll-like receptor 4 knockout (tl4r(−/−)) mice, we addressed...

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Autores principales: Hu, Guochang, Malik, Asrar B., Minshall, Richard D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739989/
https://ncbi.nlm.nih.gov/pubmed/19789446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0b013e3181bc7c17
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