Ataxin-2 Modulates the Levels of Grb2 and Src but Not Ras Signaling

Ataxin-2 (ATXN2) is implicated mainly in mRNA processing. Some ATXN2 associates with receptor tyrosine kinases (RTK), inhibiting their endocytic internalization through interaction of proline-rich domains (PRD) in ATXN2 with SH3 motifs in Src. Gain of function of ATXN2 leads to neuronal atrophy in t...

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Detalhes bibliográficos
Main Authors: Drost, Jessica, Nonis, David, Eich, Florian, Leske, Oliver, Damrath, Ewa, Brunt, Ewout R., Lastres-Becker, Isabel, Heumann, Rolf, Nowock, Joachim, Auburger, Georg
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739869/
https://ncbi.nlm.nih.gov/pubmed/23335000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12031-012-9949-4
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