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Ataxin-2 Modulates the Levels of Grb2 and Src but Not Ras Signaling
Ataxin-2 (ATXN2) is implicated mainly in mRNA processing. Some ATXN2 associates with receptor tyrosine kinases (RTK), inhibiting their endocytic internalization through interaction of proline-rich domains (PRD) in ATXN2 with SH3 motifs in Src. Gain of function of ATXN2 leads to neuronal atrophy in t...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Springer US
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3739869/ https://ncbi.nlm.nih.gov/pubmed/23335000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12031-012-9949-4 |
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