MAMMALIAN ATAXIN-2 MODULATES TRANSLATION CONTROL AT THE PRE-INITITATION COMPLEX VIA PI3K/MTOR AND IS INDUCED BY STARVATION

Ataxin-2 is a cytoplasmic protein, product of the ATXN2 gene, whose deficiency leads to obesity, while its gain-of-function leads to neural atrophy. Ataxin-2 affects RNA homeostasis, but its effects are unclear. Here, immunofluorescence analysis suggested that ataxin-2 associates with 48S pre-initia...

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Publicado en:Biochim Biophys Acta
Autores principales: Lastres-Becker, Isabel, Nonis, David, Eich, Florian, Klinkenberg, Michael, Gorospe, Myriam, Kötter, Peter, Klein, Fabrice A. C., Kedersha, Nancy, Auburger, Georg
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967000/
https://ncbi.nlm.nih.gov/pubmed/27240544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2016.05.017
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