Genetic ablation of ataxin-2 increases several global translation factors in their transcript abundance but decreases translation rate

Spinocerebellar ataxia type 2 (SCA2) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders, caused or modified by an unstable CAG-repeat expansion in the SCA2 gene, which encodes a polyglutamine (polyQ) domain expansion in ataxin-2 (ATXN2). ATXN2 is an RNA-binding protein and inter...

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Publicado en:Neurogenetics
Main Authors: Fittschen, M., Lastres-Becker, I., Halbach, M. V., Damrath, E., Gispert, S., Azizov, M., Walter, M., Müller, S., Auburger, G.
Formato: Artigo
Idioma:Inglês
Publicado: Springer Berlin Heidelberg 2015
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4475250/
https://ncbi.nlm.nih.gov/pubmed/25721894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10048-015-0441-5
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