ATXN2-CAG42 Sequesters PABPC1 into Insolubility and Induces FBXW8 in Cerebellum of Old Ataxic Knock-In Mice

Spinocerebellar Ataxia Type 2 (SCA2) is caused by expansion of a polyglutamine encoding triplet repeat in the human ATXN2 gene beyond (CAG)(31). This is thought to mediate toxic gain-of-function by protein aggregation and to affect RNA processing, resulting in degenerative processes affecting prefer...

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Detalhes bibliográficos
Main Authors: Damrath, Ewa, Heck, Melanie V., Gispert, Suzana, Azizov, Mekhman, Nowock, Joachim, Seifried, Carola, Rüb, Udo, Walter, Michael, Auburger, Georg
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431311/
https://ncbi.nlm.nih.gov/pubmed/22956915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002920
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