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A Type-II Positive Allosteric Modulator of α7 nAChRs Reduces Brain Injury and Improves Neurological Function after Focal Cerebral Ischemia in Rats

In the absence of clinically-efficacious therapies for ischemic stroke there is a critical need for development of new therapeutic concepts and approaches for prevention of brain injury secondary to cerebral ischemia. This study tests the hypothesis that administration of PNU-120596, a type-II posit...

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Autors principals: Sun, Fen, Jin, Kunlin, Uteshev, Victor V.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739732/
https://ncbi.nlm.nih.gov/pubmed/23951360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073581
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