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High therapeutic potential of positive allosteric modulation of α7 nAChRs in a rat model of traumatic brain injury: Proof-of-concept

There are currently no clinically-efficacious drug therapies to treat brain damage secondary to traumatic brain injury (TBI). In this proof-of-concept study, we used a controlled cortical impact model of TBI in young adult rats to explore a novel promising approach that utilizes PNU-120596, a previo...

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Detalhes bibliográficos
Publicado no:Brain Res Bull
Main Authors: Gatson, Joshua W., Simpkins, James W., Uteshev, Victor V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352406/
https://ncbi.nlm.nih.gov/pubmed/25647232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainresbull.2015.01.008
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