A positive allosteric modulator of α7 nAChRs augments neuroprotective effects of endogenous nicotinic agonists in cerebral ischaemia

BACKGROUND AND PURPOSE: Activation of α7 nicotinic acetylcholine receptors (nAChRs) can be neuroprotective. However, endogenous choline and ACh have not been regarded as potent neuroprotective agents because physiological levels of choline/ACh do not produce neuroprotective levels of α7 activation....

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Detalhes bibliográficos
Main Authors: Kalappa, Bopanna I, Sun, Fen, Johnson, Stephen R, Jin, Kunlin, Uteshev, Victor V
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753841/
https://ncbi.nlm.nih.gov/pubmed/23713819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12247
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