Integrated phosphoproteomic and metabolomic profiling reveals NPM-ALK–mediated phosphorylation of PKM2 and metabolic reprogramming in anaplastic large cell lymphoma

The mechanisms underlying the pathogenesis of the constitutively active tyrosine kinase nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) expressing anaplastic large cell lymphoma are not completely understood. Here we show using an integrated phosphoproteomic and metabolomic strategy that NPM-ALK...

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Hlavní autoři: McDonnell, Scott R. P., Hwang, Steven R., Rolland, Delphine, Murga-Zamalloa, Carlos, Basrur, Venkatesha, Conlon, Kevin P., Fermin, Damian, Wolfe, Thomas, Raskind, Alexander, Ruan, Chunhai, Jiang, Jian-Kang, Thomas, Craig J., Hogaboam, Cory M., Burant, Charles F., Elenitoba-Johnson, Kojo S. J., Lim, Megan S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2013
Témata:
Lymphoid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739039/
https://ncbi.nlm.nih.gov/pubmed/23814019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-01-482026
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