Integrated phosphoproteomic and metabolomic profiling reveals NPM-ALK–mediated phosphorylation of PKM2 and metabolic reprogramming in anaplastic large cell lymphoma

The mechanisms underlying the pathogenesis of the constitutively active tyrosine kinase nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) expressing anaplastic large cell lymphoma are not completely understood. Here we show using an integrated phosphoproteomic and metabolomic strategy that NPM-ALK...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: McDonnell, Scott R. P., Hwang, Steven R., Rolland, Delphine, Murga-Zamalloa, Carlos, Basrur, Venkatesha, Conlon, Kevin P., Fermin, Damian, Wolfe, Thomas, Raskind, Alexander, Ruan, Chunhai, Jiang, Jian-Kang, Thomas, Craig J., Hogaboam, Cory M., Burant, Charles F., Elenitoba-Johnson, Kojo S. J., Lim, Megan S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2013
Fag:
Lymphoid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739039/
https://ncbi.nlm.nih.gov/pubmed/23814019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-01-482026
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker