Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy

The nuclear receptor Rev-erb-α modulates hepatic lipid and glucose metabolism, adipogenesis and the inflammatory response in macrophages. We show here that Rev-erb-α is highly expressed in oxidative skeletal muscle and plays a role in mitochondrial biogenesis and oxidative function, in gain- and los...

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Autors principals: Woldt, Estelle, Sebti, Yasmine, Solt, Laura A., Duhem, Christian, Lancel, Steve, Eeckhoute, Jérôme, Hesselink, Matthijs K.C., Paquet, Charlotte, Delhaye, Stéphane, Shin, Youseung, Kamenecka, Theodore M., Schaart, Gert, Lefebvre, Philippe, Nevière, Rémi, Burris, Thomas P., Schrauwen, Patrick, Staels, Bart, Duez, Hélène
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737409/
https://ncbi.nlm.nih.gov/pubmed/23852339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3213
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