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p53 Ser15 phosphorylation and histone modifications contribute to IR-induced miR-34a transcription in mammary epithelial cells

Previous studies have demonstrated that miR-34a is a direct transcriptional target of tumor suppressor p53 and plays a crucial role in p53-mediated biological processes, such as cell cycle arrest, apoptosis and senescence. However, the role of p53 phosphorylation at Ser15 and histone modifications i...

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Bibliografski detalji
Glavni autori: Wang, Bo, Li, Dongping, Kovalchuk, Olga
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737310/
https://ncbi.nlm.nih.gov/pubmed/23759592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.25135
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