Fancd2 and p21 function independently in maintaining the size of hematopoietic stem and progenitor cell pool in mice

Fanconi anemia patients suffer from progressive bone marrow failure. An overactive p53 response to DNA damage contributes to the progressive elimination of Fanconi anemia hematopoietic stem and progenitor cells (HSPC), and hence presents a potential target for therapeutic intervention. To investigat...

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Bibliografiske detaljer
Main Authors: Zhang, Qing-Shuo, Watanabe-Smith, Kevin, Schubert, Kathryn, Major, Angela, Sheehan, Andrea M., Marquez-Loza, Laura, Hanlon Newell, Amy E., Benedetti, Eric, Joseph, Eric., Olson, Susan, Grompe, Markus
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737285/
https://ncbi.nlm.nih.gov/pubmed/23721813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.scr.2013.04.010
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