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Antidepressants, metoprolol and the risk of bradycardia

Case reports and pharmacologic theory suggest that some antidepressants can interfere with the hepatic metabolism of metoprolol by cytochrome P450 2D6 (CYP2D6), potentially increasing the risk of bradycardia. The objective of this study was to characterize the clinical consequences of this potential...

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Detalhes bibliográficos
Main Authors: Kurdyak, Paul A., Manno, Michael, Gomes, Tara, Mamdani, Muhammad M., Juurlink, David N.
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3736934/
https://ncbi.nlm.nih.gov/pubmed/23983956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2045125311433580
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