Venous malformation-causative TIE2 mutations mediate an AKT-dependent decrease in PDGFB

Mutations in the endothelial cell (EC) tyrosine kinase receptor TIE2 cause inherited and sporadic forms of venous malformation. The recurrent somatic mutation L914F and common germline mutation R849W differ in terms of phosphorylation level, as well as sub-cellular localization and trafficking of th...

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Bibliografiske detaljer
Main Authors: Uebelhoer, Melanie, Nätynki, Marjut, Kangas, Jaakko, Mendola, Antonella, Nguyen, Ha-Long, Soblet, Julie, Godfraind, Catherine, Boon, Laurence M., Eklund, Lauri, Limaye, Nisha, Vikkula, Miikka
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2013
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3736867/
https://ncbi.nlm.nih.gov/pubmed/23633549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt198
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