Interaction of the Complexin Accessory Helix with the C-Terminus of the SNARE Complex: Molecular-Dynamics Model of the Fusion Clamp

SNARE complexes form between the synaptic vesicle protein synaptobrevin and the plasma membrane proteins syntaxin and SNAP25 to drive membrane fusion. A cytosolic protein, complexin (Cpx), binds to the SNARE bundle, and its accessory helix (AH) functions to clamp synaptic vesicle fusion. We performe...

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Detalhes bibliográficos
Main Authors: Bykhovskaia, Maria, Jagota, Anand, Gonzalez, Agustin, Vasin, Alexander, Littleton, J. Troy
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2013
Assuntos:
Membrane
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3736676/
https://ncbi.nlm.nih.gov/pubmed/23931316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.06.018
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