Bmi1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor

The polycomb group gene Bmi1 is required for maintenance of adult stem cells in many organs(1, 2). Inactivation of Bmi1 leads to impaired stem cell self-renewal due to deregulated gene expression. One critical target of BMI1 is Ink4a/Arf, which encodes the cell cycle inhibitors p16(ink4a) and p19(Ar...

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Hauptverfasser: Biehs, Brian, Hu, Jimmy Kuang-Hsien, Strauli, Nicolas B., Sangiorgi, Eugenio, Jung, Heekyung, Heber, Ralf-Peter, Ho, Sunita, Goodwin, Alice F., Dasen, Jeremy S., Capecchi, Mario R., Klein, Ophir D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3735916/
https://ncbi.nlm.nih.gov/pubmed/23728424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2766
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