Bmi1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor

The polycomb group gene Bmi1 is required for maintenance of adult stem cells in many organs(1, 2). Inactivation of Bmi1 leads to impaired stem cell self-renewal due to deregulated gene expression. One critical target of BMI1 is Ink4a/Arf, which encodes the cell cycle inhibitors p16(ink4a) and p19(Ar...

全面介紹

Na minha lista:
書目詳細資料
Main Authors: Biehs, Brian, Hu, Jimmy Kuang-Hsien, Strauli, Nicolas B., Sangiorgi, Eugenio, Jung, Heekyung, Heber, Ralf-Peter, Ho, Sunita, Goodwin, Alice F., Dasen, Jeremy S., Capecchi, Mario R., Klein, Ophir D.
格式: Artigo
語言:Inglês
出版: 2013
主題:
Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3735916/
https://ncbi.nlm.nih.gov/pubmed/23728424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2766
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

相似書籍