Cardiac Surgical Delivery of the Sarcoplasmic Reticulum Calcium ATPase Rescues Myocytes in Ischemic Heart Failure

BACKGROUND: The sarcoplasmic reticulum calcium ATPase (SERCA2a) is an important molecular regulator of contractile dysfunction in heart failure. Gene transfer of SERCA2a mediated by molecular cardiac surgery with recirculating delivery (MCARD) is a novel and clinically translatable strategy. METHODS...

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Hlavní autoři: Fargnoli, Anthony S., Katz, Michael G., Yarnall, Charles, Isidro, Alice, Petrov, Michael, Steuerwald, Nury, Ghosh, Sriparna, Richardville, Kyle C., Hillesheim, Richard, Williams, Richard D., Kohlbrenner, Erik, Stedman, Hansell H., Hajjar, Roger J., Bridges, Charles R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3735816/
https://ncbi.nlm.nih.gov/pubmed/23773730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.athoracsur.2013.04.021
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