Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

Concentrations of acetyl–coenzyme A and nicotinamide adenine dinucleotide (NAD(+)) affect histone acetylation and thereby couple cellular metabolic status and transcriptional regulation. We report that the ketone body d-β-hydroxybutyrate (βOHB) is an endogenous and specific inhibitor of class I hist...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Shimazu, Tadahiro, Hirschey, Matthew D., Newman, John, He, Wenjuan, Shirakawa, Kotaro, Le Moan, Natacha, Grueter, Carrie A., Lim, Hyungwook, Saunders, Laura R., Stevens, Robert D., Newgard, Christopher B., Farese, Robert V., de Cabo, Rafael, Ulrich, Scott, Akassoglou, Katerina, Verdin, Eric
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3735349/
https://ncbi.nlm.nih.gov/pubmed/23223453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1227166
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