Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

Concentrations of acetyl–coenzyme A and nicotinamide adenine dinucleotide (NAD(+)) affect histone acetylation and thereby couple cellular metabolic status and transcriptional regulation. We report that the ketone body d-β-hydroxybutyrate (βOHB) is an endogenous and specific inhibitor of class I hist...

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Detalhes bibliográficos
Main Authors: Shimazu, Tadahiro, Hirschey, Matthew D., Newman, John, He, Wenjuan, Shirakawa, Kotaro, Le Moan, Natacha, Grueter, Carrie A., Lim, Hyungwook, Saunders, Laura R., Stevens, Robert D., Newgard, Christopher B., Farese, Robert V., de Cabo, Rafael, Ulrich, Scott, Akassoglou, Katerina, Verdin, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3735349/
https://ncbi.nlm.nih.gov/pubmed/23223453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1227166
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