Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

Concentrations of acetyl–coenzyme A and nicotinamide adenine dinucleotide (NAD(+)) affect histone acetylation and thereby couple cellular metabolic status and transcriptional regulation. We report that the ketone body d-β-hydroxybutyrate (βOHB) is an endogenous and specific inhibitor of class I hist...

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Bibliografiske detaljer
Main Authors: Shimazu, Tadahiro, Hirschey, Matthew D., Newman, John, He, Wenjuan, Shirakawa, Kotaro, Le Moan, Natacha, Grueter, Carrie A., Lim, Hyungwook, Saunders, Laura R., Stevens, Robert D., Newgard, Christopher B., Farese, Robert V., de Cabo, Rafael, Ulrich, Scott, Akassoglou, Katerina, Verdin, Eric
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3735349/
https://ncbi.nlm.nih.gov/pubmed/23223453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1227166
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