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Improved synthesis of N1-substituted orotic acid derivatives

An improved method for the synthesis of N1-substituted orotic acid derivatives is reported. The method involves sequential incorporation of nitrogen atoms to the pyrimidine structure from simple starting materials and thus allows the synthesis of N1-substituted orotic acid derivatives with single (1...

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Detalhes bibliográficos
Main Authors: Senger, Nicholas A., Bowler, Jeannette T., Mercado, Rene S., Lin, Sidney, Wu, Weiming
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3735222/
https://ncbi.nlm.nih.gov/pubmed/23935222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2013.05.136
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