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Transgene-driven expression of the Doppel protein in Purkinje cells causes Purkinje cell degeneration and motor impairment

The Doppel (Dpl) and Prion (PrP) proteins show 25% sequence identity and share several structural features with only minor differences. Dpl shows a PrP-like fold of its C-terminal globular domain and lacks the flexible N-terminal tail. The physiological functions of both proteins are unknown. Howeve...

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Bibliografiske detaljer
Main Authors: Anderson, Lucy, Rossi, Daniela, Linehan, Jackie, Brandner, Sebastian, Weissmann, Charles
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC373516/
https://ncbi.nlm.nih.gov/pubmed/15007176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308681101
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