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Autophagy and Cell Death of Purkinje Cells Overexpressing Doppel in Ngsk Prnp‐deficient Mice
In Ngsk prion protein (PrP)‐deficient mice (NP(0/0)), ectopic expression of PrP‐like protein Doppel (Dpl) in central neurons induces significant Purkinje cell (PC) death resulting in late‐onset ataxia. NP(0/0) PC death is partly prevented by either knocking‐out the apoptotic factor BAX or overexpres...
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| Publicado no: | Brain Pathol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8094811/ https://ncbi.nlm.nih.gov/pubmed/19055638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1750-3639.2008.00245.x |
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