Autophagy and Cell Death of Purkinje Cells Overexpressing Doppel in Ngsk Prnp‐deficient Mice

In Ngsk prion protein (PrP)‐deficient mice (NP(0/0)), ectopic expression of PrP‐like protein Doppel (Dpl) in central neurons induces significant Purkinje cell (PC) death resulting in late‐onset ataxia. NP(0/0) PC death is partly prevented by either knocking‐out the apoptotic factor BAX or overexpres...

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Bibliografiske detaljer
Udgivet i:Brain Pathol
Main Authors: Heitz, Stéphane, Grant, Nancy J., Leschiera, Raphael, Haeberlé, Anne‐Marie, Demais, Valérie, Bombarde, Guy, Bailly, Yannick
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2008
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8094811/
https://ncbi.nlm.nih.gov/pubmed/19055638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1750-3639.2008.00245.x
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