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Doppel Induces Degeneration of Cerebellar Purkinje Cells Independently of Bax
Doppel (Dpl) is a prion protein paralog that causes neurodegeneration when expressed ectopically in the brain. To investigate the cellular mechanism underlying this effect, we analyzed Dpl-expressing transgenic mice in which the gene for the proapoptotic protein Bax had been deleted. We found that B...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Investigative Pathology
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1934519/ https://ncbi.nlm.nih.gov/pubmed/17569776 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.070262 |
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