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Doppel Induces Degeneration of Cerebellar Purkinje Cells Independently of Bax

Doppel (Dpl) is a prion protein paralog that causes neurodegeneration when expressed ectopically in the brain. To investigate the cellular mechanism underlying this effect, we analyzed Dpl-expressing transgenic mice in which the gene for the proapoptotic protein Bax had been deleted. We found that B...

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Hlavní autoři: Dong, Jiaxin, Li, Aimin, Yamaguchi, Naohiro, Sakaguchi, Suehiro, Harris, David A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1934519/
https://ncbi.nlm.nih.gov/pubmed/17569776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.070262
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