Doppel-induced cerebellar degeneration in transgenic mice

Doppel (Dpl) is a paralog of the mammalian prion protein (PrP); it is abundant in testes but expressed at low levels in the adult central nervous system. In two Prnp-deficient (Prnp(0/0)) mouse lines (Ngsk and Rcm0), Dpl overexpression correlated with ataxia and death of cerebellar neurons. To deter...

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Main Authors: Moore, Richard C., Mastrangelo, Peter, Bouzamondo, Essia, Heinrich, Cornelia, Legname, Giuseppe, Prusiner, Stanley B., Hood, Leroy, Westaway, David, DeArmond, Stephen J., Tremblay, Patrick
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2001
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC65022/
https://ncbi.nlm.nih.gov/pubmed/11734625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.251550798
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