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Toll-like receptor 3-mediated activation of NF-κB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-β
We have previously shown that double-stranded RNA-triggered, Toll-like receptor 3 (TLR3)-mediated signaling is independent of MyD88, IRAK4, and IRAK. Instead, TRAF6, TAK1, and TAB2 are recruited to TLR3 on poly(I·C) stimulation. TRAF6-TAK1-TAB2 are then translocated to the cytosol where TAK1 is phos...
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| Опубликовано в: : | Proc Natl Acad Sci U S A |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2004
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC373497/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14982987/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0308496101 |
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