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IRF-3-dependent, NFκB- and JNK-independent activation of the 561 and IFN-β genes in response to double-stranded RNA

Double-stranded (ds) RNA induces transcription of the 561 gene by activating IFN regulatory factor (IRF) transcription factors, whereas similar induction of the IFN-β gene is thought to require additional activation of NFκB and AP-1. In mutant P2.1 cells, dsRNA failed to activate NFκB, IRF-3, p38, o...

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Detalhes bibliográficos
Main Authors: Peters, Kristi L., Smith, Heather L., Stark, George R., Sen, Ganes C.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC122947/
https://ncbi.nlm.nih.gov/pubmed/11972054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.092133199
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