PKC signaling prevents irradiation-induced apoptosis of primary human fibroblasts

Primary cells respond to irradiation by activation of the DNA damage response and cell cycle arrest, which eventually leads to senescence or apoptosis. It is not clear in detail which signaling pathways or networks regulate the induction of either apoptosis or senescence. Primary human fibroblasts a...

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Bibliographic Details
Main Authors: Bluwstein, A, Kumar, N, Léger, K, Traenkle, J, Oostrum, J van, Rehrauer, H, Baudis, M, Hottiger, M O
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2013
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734826/
https://ncbi.nlm.nih.gov/pubmed/23412390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.15
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